No, E=mc2 demonstrates that mass and energy are one in the same. When converting mass to energy, nothing is being destroyed, merely changing state. As far as we are aware, the absolute destruction or removal of energy, and thereby matter, from the Universe is not possible.
E=mc2 is the equation for how much energy is created by destroying a given amount of mass.
No, E=mc2 demonstrates that mass and energy are one in the same. When converting mass to energy, nothing is being destroyed, merely changing state. As far as we are aware, the absolute destruction or removal of energy, and thereby matter, from the Universe is not possible.