Maybe there’s something that I’m still missing, but the genders could be any which way and it would still give the same meaning: fucking or screwing someone over. It’s vulgar and tasteless but I don’t think it is necessarily homophobic or misogynistic.

It does simply imply someone is being (sexually) dominated by another, but there’s no placement of “good” or “bad”—just that Microsoft users are being dominated by Microsoft, which is roughly true. I do think it’s a crude analogy and a terrible meme, but to say it’s anything more seems like a stretch.